Karen Santry's avant garde paintings reflect her interest and training in haute couture.   She exhibited a number of her paintings in Audart's "Shrines to Fantasy" exhibition, creating a room-sized installation which included her giant "Golden Girls" cutouts.  

Santry's work has been exhibited extensively, both nationally and internationally, at the Solomon Guggenheim, the Whitney Museum Store Gallery, the New Museum of Contemporary Art, the Smithsonian Institute, European and Japanese museums and numerous art galleries in the United States and abroad.